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Ehlers-Danlos syndrome (EDS) is a heterogeneous group of congenital connective tissue diseases caused by mutations in genes involved in the synthesis or processing of collagen fibers.1 The phenotypic manifestations of EDS vary greatly, and mild cases can go unnoticed until late in life

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Next, we used Hi-C coupled MAGMA (H-MAGMA) 20 , which investigates gene associations by encompassing regulatory SNPs based on chromatin interactions within a cell ( cis -eQTLs and trans -eQTLs [long distance regulatory variants])

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